2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-131284
    (S)-Dehydro Venlafaxine
    (S)-Dehydro Venlafaxine is an inactive S-enantiomer of Dehydro Venlafaxine. Dehydro Venlafaxine is an impurity of Venlafaxine hydrochloride. Venlafaxine hydrochloride (Wy 45030 hydrochloride) is a potent serotonin (5-HT) / norepinephrine (NE) reuptake dual inhibitor.
    (S)-Dehydro Venlafaxine
  • HY-129889
    Febuxostat acyl glucuronide
    Febuxostat acyl glucuronide (Febuxostat acyl-β-D-glucuronide) is a metabolite of Febuxostat (HY-14268). Febuxostat is a potent, selective and non-purine xanthine oxidase (XO) inhibitor.
    Febuxostat acyl glucuronide
  • HY-13318S1
    Oseltamivir acid-13C,d3
    Oseltamivir acid-13C,d3 (GS 4071-13C,d3; Ro 64-0802-13C,d3) is a 13C- and deuterium-labeled Oseltamivir acid (HY-13318). Oseltamivir acid is the active metabolite of Oseltamivir phosphate and inhibits influenza virus neuraminidase (IC50=2 nM). Oseltamivir acid is orally active and can be used to study influenza A/B infections.
    Oseltamivir acid-<sup>13</sup>C,d<sub>3</sub>
  • HY-113442
    6-trans-12-epi-Leukotriene B4
    6-trans-12-epi-Leukotriene B4, an arachidonic acid metabolite, is a potent anti-inflammatory agent.
    6-trans-12-epi-Leukotriene B4
  • HY-149503
    4-Hydroxy nebivolol hydrochloride
    4-Hydroxy nebivolol (4-OH nebivolol) hydrochloride is an active β-blocking hydroxylated metabolite of Nebivolol (HY-B0203).
    4-Hydroxy nebivolol hydrochloride
  • HY-W008449S2
    1-Methylxanthine-d3
    1-Methylxanthine-d3 is deuterated labeled 1-Methylxanthine (HY-W008449). 1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP). 1-Methylxanthine enhances the radiosensitivity of tumor cells.
    1-Methylxanthine-d<sub>3</sub>
  • HY-135381
    3-Oxo Atorvastatin
    3-Oxo Atorvastatin is an impurity of 3-Oxo Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids.
    3-Oxo Atorvastatin
  • HY-W019773S1
    Albendazole sulfone-d3
    Albendazole sulfone-d3 is the deuterium labeled Albendazole sulfone. Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes.
    Albendazole sulfone-d<sub>3</sub>
  • HY-138094
    N-(2-Hydroxyethyl)oxamic acid
    N-(2-hydroxyethyl)-oxamic acid is formed when Metronidazole is reduced either chemically or by the action of the intestinal bacteria. Metronidazole, a nitroimidazole antibiotic, has activity against various protozoans and most Gram-negative and Gram-positive anaerobic bacteria.
    N-(2-Hydroxyethyl)oxamic acid
  • HY-148376
    Abiraterone N-oxide
    Abiraterone N-oxide is a metabolite of Abiraterone (HY-148377). Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity.
    Abiraterone N-oxide
  • HY-145949
    Remdesivir de(ethylbutyl 2-aminopropanoate)
    Remdesivir de(ethylbutyl 2-aminopropanoate) is an impurity of Remdesivir. Remdesivir, a nucleoside analogue with effective antiviral activity, has EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro.
    Remdesivir de(ethylbutyl 2-aminopropanoate)
  • HY-161487
    AOZ/BSA
    AOZ/BSA is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    AOZ/BSA
  • HY-137117
    15-keto-PGE1
    15-keto-PGE1 is an inactive Prostaglandin E1 (PGE1) metabolite. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation.
    15-keto-PGE1
  • HY-107856R
    5-Fluorouridine (Standard)
    5-Fluorouridine (Standard) is the analytical standard of 5-Fluorouridine. This product is intended for research and analytical applications. 5-Fluorouridine, a metabolite of 5-fluorouracil (HY-90006), is a potent ribozyme self-cleavage inhibitor. 5-Fluorouridine incorporates into both total and poly A RNA and has antiproliferative activity. 5-Fluorouridine induces apoptosis.
    5-Fluorouridine (Standard)
  • HY-134611
    (2-Hydroxyethoxy)acetic acid
    (2-Hydroxyethoxy)acetic acid (β-hydroxyethoxyacetic acid) is the main urinary metabolite of 1,4-Dioxane. (2-Hydroxyethoxy)acetic acid is a reliable and sensitive shortterm biomarker in urine.
    (2-Hydroxyethoxy)acetic acid
  • HY-151930S
    8′-Hydroxy ABA-d8
    8′-Hydroxy ABA-d8 is the deuterium labeled 8’-Hydroxy ABA[1].
    8′-Hydroxy ABA-d<sub>8</sub>
  • HY-N11676
    6-Hydroxy-TSU-68
    6-Hydroxy-TSU-68 is a derivative of TSU-68 (HY-10517). It is a metabolite of the biotransformation pathway of TSU-68 in human liver microsomes. The content represents the self-induced hydroxylation level of TSU-68.
    6-Hydroxy-TSU-68
  • HY-N2396
    N-(3-Methoxybenzyl-(9z,12z)-octadecadienamide
    N-​(3-​Methoxybenzyl-​(9z,​12z)​-​octadecadienamide (Macamide impurity 10) is the impurity of Macamide.
    N-(3-Methoxybenzyl-(9z,12z)-octadecadienamide
  • HY-142592S
    Clozapine EP impurity D-d8
    Clozapine EP impurity D-d8 is the deuterium labeled Clozapine EP impurity D[1].
    Clozapine EP impurity D-d<sub>8</sub>
  • HY-117580S
    16α-Hydroxyprednisolone-d3
    16α-Hydroxyprednisolone-d3 is the deuterium labeled 16α-Hydroxyprednisolone. 16α-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid budesonide via cytochrome P450 3A (CYP3A) enzymes[1][2].
    16α-Hydroxyprednisolone-d<sub>3</sub>
Cat. No. Product Name / Synonyms Application Reactivity